材料科学与化学工程学院学术报告——Transition Metal-Free Decarboxylative Iodination: New Routes for Decarboxylative Oxidative Cross-Couplings
Greg Perry received his MChem from the University of Liverpool (UK) where he worked under the supervision of Professor P. Andrew Evans. He then joined the group of Professor Igor Larrosa and was awarded his PhD from the University of Manchester (UK) in 2016. His doctoral studies focused on the development of decarboxylative and C–H transformations for organic synthesis. He is currently a Postdoctoral Fellow at Nagoya University (Japan) working in the lab of Professor Kenichiro Itami where he is developing methods for the rapid synthesis of biology- and materials-oriented aromatics via C–H functionalisation.
In recent years, decarboxylative and C–H functionalisations have gained significant interest as efficient routes for the functionalisation of aryl molecules. In this talk, a simple and inexpensive method for the decarboxylative iodination of benzoic acids will be presented. This method affords synthetically useful aryl iodides which can then be coupled with arenes or benzoic acids to afford biaryl molecules – common structures found in functional molecules from blockbuster drug molecules to day-to-day electronic devices.